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![]() Physiologic blood plasma osmolarity is approximately 286 mOsmoles/L. Osmolarity is defined as the number of particles per liter of fluid. įluid moves throughout cellular environments in the body by passively crossing semipermeable membranes. Intracellular fluids tend to be inversed with high levels of phosphate, magnesium, potassium, and proteins but lower sodium, chloride, and bicarbonate. Interstitial fluids physiologically tend to have a low concentration of proteins. Extracellular spaces contain high concentrations of sodium, chloride, bicarbonate, and proteins but are relatively lower in potassium, magnesium, and phosphate. Extracellular fluid and interstitial fluid are similar in composition. The exact chemical composition of body fluid is highly variable. This is dependent on which portion of the body, as well as which organ of the body, contains the fluid. Additional fluid spaces are possible in pathological scenarios and are categorized as a transudate or exudate based on location and etiology. The extracellular fluid comprises approximately 20% of total body weight and further subcategorizes as plasma at approximately 5% of body weight and interstitial space which is approximately 12% of body weight. This space is where much of chemical reactions occur, as such, it is important to maintain an appropriate osmolality. In general, intracellular fluids are stable and do not readily adjust to rapid changes. It is the total space within cells primarily defined as the cytoplasm of cells. Intracellular fluid is approximately 40% of the total body weight. Syphilis, cryptococcosis, and tuberculosis are much more common in patients who have AIDS than in the general population.The distribution of fluid throughout the body can be broken down into two general categories: intracellular fluid and extracellular fluid. Tuberculous meningitis may sometimes be diagnosed with Ziehl-Neelsen stains, but more often this is done with cultures. Cryptococcal infection of the CSF may be demonstrated by India ink preparations, or by latex agglutination tests. Syphilitic meningitis is usually diagnosed with serological tests for the disease, such as the venereal disease research laboratory (VDRL) test, the rapid plasma reagin (RPR) test, or the fluorescent treponemal antibody test. Meningococci, streptococci, Haemophilus influenzae, Listeria monocytogenes, and gram-negative bacilli are recovered from the CSF only in cases of meningitis. Malignant cells in the CSF, demonstrated after centrifugation or filtering, are hallmarks of carcinomatous meningitis. ![]() ![]() ![]() The concentration of glucose in the CSF rises in uncontrolled diabetes mellitus and drops precipitously in meningitis, sarcoidosis, and some other illnesses. Many conditions may cause increases in CSF total protein: infections, such as acute or chronic meningitis multiple sclerosis (when oligoclonal protein bands are present) Guillain-Barré syndrome and chronic medical conditions like cirrhosis and hypothyroidism (when diffuse hypergammaglobulinemia is present). Centrifugation of the fluid can distinguish between these two sources of blood in the spinal fluid: the supernatant is usually stained yellow (xanthochromic) only when there has been a recent subarachnoid hemorrhage. Turbidity suggests an excessively high number of cells in the fluid, typically white blood cells in infections such as meningitis or red blood cells in intracerebral hemorrhage.ĬSF may appear red following a recent subarachnoid hemorrhage or when the lumbar puncture that obtained the CSF caused traumatic injury to the dura that surround the fluid. Its concentration and alkaline reserve are similar to those of blood. Its pH, which is rarely measured clinically, is slightly more acidic than the pH of blood. On average, the total protein is about 15 to 50 mg/dL, and the concentration of glucose is about two thirds the concentration of glucose in the patient's serum. The initial pressure of spinal fluid in a side-lying adult is about 100 to 180 mm of water. Body fluid compartments transcellular free#The fluid is normally watery, clear, colorless, and almost entirely free of cells. FLOW OF CEREBROSPINAL FLUID THROUGH THE BRAIN AND SPINAL COLUMN Formation, circulation, and reabsorption of CSF ![]() |
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